Difference Between Kupffer Cells and Hepatocytes

Hepatocytes secrete bile into canaliculi that are defined by junctions between hepatocytes. Bile flows through theses narrow tubes toward the bile duct. Also visible is a Kupffer cell. Kupffer cells are the resident macrophages of the liver and are typically found within the lumen of the sinusoids.

1. Are Kupffer cells hepatocytes?
2. What is the function of Kupffer cells in the hepatic lobule?
3. What type of cell is a hepatocyte?
4. What are the functions of hepatocytes?
5. What do Kupffer cells secrete?
6. What are liver cells called?
7. Where do Kupffer cells originate?
8. What are Sinusoids?
9. Which is not a function of the liver?
10. What is a hepatocyte cell?
11. What organelle is the brain of the cell?
12. What do hepatocytes look like?

Are Kupffer cells hepatocytes?

It is composed of 60% parenchymal cells, i.e., hepatocytes, and 30% to 35% non-parenchymal cells, i.e., Kupffer cells (KCs), hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) [1].

What is the function of Kupffer cells in the hepatic lobule?

The main role of Kupffer cells is to clear foreign debris and particles from the portal system circulation that pass the liver. Kupffer cells can ingest large particles via phagocytosis and small particles and molecules via pinocytosis.

What type of cell is a hepatocyte?

Hepatocyte function. The hepatocytes (epithelial cells of the liver) form branching plates of cells, often only one cell thick, between a system of capillary sinusoids that connect the portal tracts to the central vein.

What are the functions of hepatocytes?

Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading microorganisms by secreting innate immunity proteins.

What do Kupffer cells secrete?

Kupffer cells can produce inflammatory cytokines, TNF-alpha, oxygen radicals, and proteases as well as performing phagocytosis. Creating these mediators is believed to lead to the development of liver injury.

What are liver cells called?

Hepatocytes. The most common cells of the liver (making up roughly 90% of the liver's cells) are called hepatocytes. They are all identical. These cells carry out most of the functions which the liver performs.

Where do Kupffer cells originate?

Kupffer cells originate in the bone marrow. These bone marrow monocytes enter the circulation and become implanted in the liver where they differentiate into fixed tissue macrophages. Kupffer cells are considered terminally differentiated and the cells no longer divide (Fig.

What are Sinusoids?

Sinusoid, irregular tubular space for the passage of blood, taking the place of capillaries and venules in the liver, spleen, and bone marrow. The sinusoids form from branches of the portal vein in the liver and from arterioles (minute arteries) in other organs.

Which is not a function of the liver?

The liver secretes bile juice. The liver plays a key role in carbohydrates metabolism, in lipid metabolism. It also helps in deamination of proteins and conversion of ammonia into urea. ... Hence, Making of red blood cells is not a function of the liver in adults.

What is a hepatocyte cell?

Liver cells, or hepatocytes, have direct access to the liver's blood supply through small capillaries called sinusoids. ... Hepatocytes carry out many metabolic functions, including the production of bile.

What organelle is the brain of the cell?

The nucleus is the 'brain' of a cell.

What do hepatocytes look like?

Hepatocyte nuclei are distinctly round, with one or two prominent nucleoli. A majority of cells have a single nucleus, but binucleate cells are common. The micrographs below (H&E stain) demonstrate these features in sections of liver from a pig (left) and raccoon (right).