Difference Between Hardness and Friability

Hardness and friability are two terms used to explain physical properties related to the strength of substances. ... The main difference between hardness and friability is that hardness is the resistance to scratch or deformation whereas friability is the tendency to crumble.

1. What is meant by friability?
2. Why do we test hardness of tablets?
3. What affects tablet friability?
4. How do you measure the friability of a tablet?
5. How do you calculate friability?
6. What is limit of friability in IP and USP?
7. What is unit of hardness?
8. How can I reduce the hardness of my tablet?
9. Which hardness tester is most widely used?
10. How do you solve friability problems?
11. What hardness of tablets can be evaluated by the use of Friabilator?
12. Why is granulation important before tableting?

What is meant by friability?

Friability (/ˌfraɪəˈbɪləti/ FRY-ə-BIL-ə-tee), the condition of being friable, describes the tendency of a solid substance to break into smaller pieces under duress or contact, especially by rubbing. ... Tougher substances, such as concrete, may also be mechanically ground down and reduced to finely divided mineral dust.

Why do we test hardness of tablets?

Tablet hardness testing, is a laboratory technique used by the pharmaceutical industry to determine the breaking point and structural integrity of a tablet and find out how it changes "under conditions of storage, transportation, packaging and handling before usage" The breaking point of a tablet is based on its shape.

What affects tablet friability?

Increased tablet hardness (and to a lesser extent decreased tablet thickness) decreased the tablet friability of the larger tablet. An increase in the quantity of granulating fluid increased the granulation particle size and slightly improved compactibility without significantly affecting friability.

How do you measure the friability of a tablet?

Accurately weigh the tablet sample and place the tablets in the drum. Rotate the drum 100 times and remove the tablets. Remove any loose dust from the tablets as before and accurately weigh. Generally the test is run once.

How do you calculate friability?

Friability is usually measured by the use of Roche fibrilator or tumbler test. A number of tablets are weighed and placed in the apparatus where they are exposed to rolling and repeated shocks as they fall 6 inches in each turn within the apparatus.

What is limit of friability in IP and USP?

Friability Test • This test is additional to check crushing strength of tablet by this test one can check Capping &/or Lamination. USP limit is 0.5 to 1%. Rotation: - 25 rpm or 100 rotations in 4 min. For tablets weight equal to or less than 650 mg, take tablets corresponding to 6.5 g.

What is unit of hardness?

The SI unit of hardness is N/mm². The unit Pascal is thus used for hardness as well but hardness must not be confused with pressure. The different types of hardness discussed above have different scales of measurement.

How can I reduce the hardness of my tablet?

Most recent answer

1. Use colloidal silicon dioxide extragranularly, will give higher hardness and solve friability issue For DC Method.
2. Use slugging process For dry granulation method.
3. Use dry binder (HPC)- For DC Method.
4. Use Gelatin with starch paste will give excellent hardness For wet granulation method.

Which hardness tester is most widely used?

Common hardness testing types include Rockwell (indentation depth or un-recovered indentation), Knoop/Vickers, and Brinell (area of indentation). Rockwell testing is the most commonly used method by virtue of the quick results generated and is typically used on metals and alloys.

How do you solve friability problems?

Press speed and the amount of clearance between the upper punch tip and the die also contributes to the air release. For many powders increasing the venting by increasing the taper or increasing the tip/die clearance, slowing the machine down, and using pre-compression correctly all contribute to improved friability.

What hardness of tablets can be evaluated by the use of Friabilator?

Hardness for compressed tablet is 5 to 8 kg. Friability of a tablet can determine in laboratory by Roche friabilator. This consist of a plastic chamber that revolves at 25 rpm, dropping the tablets through a Distance of six inches in the friabilator, which is then operate for 100 revolutions. The tablets are reweighed.

Why is granulation important before tableting?

Granulation process is an inevitable step in tablet manufacturing as it improves flow property and compressibility of powder mass intended for compression. Granulation prevents segregation of the constituents of the powder mix.