Difference Between G CSF and GM CSF

G-CSF induces the appearance of colonies containing only granulocytes, while GM-CSF gave colonies containing both granulocytes and macrophages. Generation of G-CSF (genomic nomenclature: Csf3) and G-CSF Receptor (Csf3r) knockout mice confirmed that G-CSF critically drives granulopoiesis(7).

1. How does G-CSF work?
2. What produces GM-CSF?
3. What is G-CSF in medical terms?
4. How is G-CSF made?
5. How quickly does G-CSF work?
6. Does G-CSF increase platelet count?
7. Is GM-CSF proinflammatory?
8. Is a macrophage a granulocyte?
9. How is G-CSF administered?
10. Can GCSF cause leukemia?
11. What is G-CSF pegfilgrastim used for?

How does G-CSF work?

Granulocyte colony-stimulating factor (G-CSF) is a blood growth factor (special proteins produced by the body) that stimulates the bone marrow to produce more infection-fighting white blood cells called neutrophils. Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated.

What produces GM-CSF?

GM-CSF is produced by various cell types including macrophages, mast cells, T cells, fibroblasts and endothelial cells ^{8, 9}, mostly in response to immune activation and cytokines that mediate inflammation.

What is G-CSF in medical terms?

G-CSF helps the bone marrow make more white blood cells. It is a type of colony-stimulating factor. Also called filgrastim and granulocyte colony-stimulating factor.

How is G-CSF made?

G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 177-amino-acid-long protein of molecular weight 19,600 grams per mole.

How quickly does G-CSF work?

This usually takes 5 to 7 days, although it can be longer. Long-acting G-CSF is given as a single injection the day after chemotherapy has completed. If you are having G-CSF before a stem cell transplant, you usually have your first injection 4 to 6 days before your stem cells are going to be collected.

Does G-CSF increase platelet count?

Primarily, G-CSF stimulates the bone marrow to produce granulocytes and stem cells. A decreased platelet count was occasionally observed after G-CSF injection. A previous study indicated that G-CSF also increases platelet turnover and loss.

Is GM-CSF proinflammatory?

In addition to its function as a hematopoietic growth factor, GM-CSF is now recognized to have a variety of functions on mature hemopoietic cells. GM-CSF enhances proinflammatory cytokine production [29], antigen presentation [30, 31], and phagocytosis [32–35] and promotes leukocyte chemotaxis and adhesion [5, 36–38].

Is a macrophage a granulocyte?

Granulocytes include neutrophils, basophils, eosinophils, and mast cells. Their granules contain enzymes that damage or digest pathogens and release inflammatory mediators into the bloodstream. Mononuclear leukocytes include lymphocytes, monocytes, macrophages, and dendritic cells.

How is G-CSF administered?

Insert the needle into the skin at a 45-degree angle with a quick firm motion. Do not press down on the top of the plunger while the needle enters the skin. After the needle is fully inserted into the skin, release the skin that you are pinching, and hold the syringe in place.

Can GCSF cause leukemia?

G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.

What is G-CSF pegfilgrastim used for?

Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, filgrastim. It is used to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with with non-myeloid cancer receiving myelosuppressive anti-cancer treatment.