Difference Between Dry and Wet Granulation

1. What is the difference between dry granulation and wet granulation?
2. What is wet granulation method?
3. What is dry granulation?
4. Which granulation method is best?
5. Why wet granulation is done?
6. Why dry granulation method is preferred?
7. What are the types of granulation?
8. What is the end point of granulation?
9. Why granulation is required?
10. What is slugging in dry granulation?
11. Why is direct compression better than granulation?
12. What is meant by granulation?

What is the difference between dry granulation and wet granulation?

The main difference between dry and wet granulation is that dry granulation is the formation of granules without using any liquid solution whereas wet granulation is the formation of granules by adding a granulating liquid.

What is wet granulation method?

Wet granulation method is a process of size enlargement in which fine powder particles are agglomerated or brought together into larger, strong and relatively permanent structure called granules using a suitable non-toxic granulating fluid such as water, isopropanol or ethanol (or mixtures thereof).

What is dry granulation?

Dry granulation is a powder agglomeration process used in the pharmaceutical industry to improve the flowability of powders by increasing the particle size (granules). This operation is achieved using a roller press, which can have different configurations and equipment designs.

Which granulation method is best?

Among these two techniques, wet granulation is the most widespread granulation technique used despite the fact that it involves multiple unit processes such as wet massing, drying and screening, which are complex, time consuming, and expensive requiring large space and multiple equipment.

Why wet granulation is done?

Wet granulation involves the massing of a mix of dry primary powder particles using a granulating fluid. ... (also referred to as a binder or binding agent) which is used to ensure particle adhesion once the granule is dry.

Why dry granulation method is preferred?

The dry granulation process is used to form granules without a liquid solution because the product granulated may be sensitive to moisture and heat. Forming granules without moisture requires compacting and densifying the powders. In this process the primary powder particles are aggregated under high pressure.

What are the types of granulation?

What are Types of Granulation?

• Wet Granulation/Agglomeration. With a Binder. Spraying Dissolved Material on Recycle.
• Melt Spray Granulation. Falling Curtain Granulation.
• Steam/Water Granulation.
• Ammoniation Granulation.
• Prilling.
• Compaction.

What is the end point of granulation?

End Point in a wet granulation process is characterized by rheological properties of the wet mass such as density, viscosity etc which are in turn a function of particle size, shape and other physical properties.

Why granulation is required?

Why is Granulation Necessary? The granulation process allows particles to stick together more firmly. It increases the particle size of the constituents used, which are mostly very fine powders. The greater the particle size of a constituent, greater will be its compressive or binding ability.

What is slugging in dry granulation?

Introduction. Slugging is a pre-compression process for the formation of extra large tablets (slugs), usually of variable weight, due to poor flow of the drug powder. The resulting slugs are subsequently broken down into granules, which are recompressed to obtain the final tablets.

Why is direct compression better than granulation?

Direct compression is a popular choice because it provides the shortest, most effective and least complex way to produce tablets. The manufacturer can blend an API with the excipient and the lubricant, followed by compression, which makes the product easy to process. No additional processing steps are required.

What is meant by granulation?

Granulation: That part of the healing process in which lumpy, pink tissue containing new connective tissue and capillaries forms around the edges of a wound. Granulation of a wound is normal and desirable.