Difference Between Co and Post Translational Modification

CO-TRANSLATIONAL MODIFICATION: Maturation of delivery of proteins during translation. POST TRANSLATIONAL MODIFICATION : Covalent and enzymatic modification of proteins after translation. 4. OVER VIEW OF TRANSLATION TRANSLATION: m - RNA is decoded by the ribosome to produce a polypeptide chain or a protein.

1. What is the difference between Cotranslational and posttranslational translocation?
2. What is meant by post-translational modification?
3. What is co translational translocation?
4. What are different types of post-translational modifications and what is their functional significance?
5. What are three types of post translational modifications?
6. Which of the following is not a type of post translational modification?
7. Where does post transcriptional modification occur?
8. How do you identify post-translational modification?
9. Where does post-translational modification?
10. Is Methylation a post translational modification?
11. What is co-translational targeting?
12. What does co-translational mean?

What is the difference between Cotranslational and posttranslational translocation?

During cotranslational translocation, the ribosome provides the motive power that pushes the growing peptide into the ER lumen. During posttranslational translocation, additional proteins are necessary to ensure that the peptide moves unidirectionally into the ER membrane.

What is meant by post-translational modification?

A posttranslational modification (PTM) is a biochemical modification that occurs to one or more amino acids on a protein after the protein has been translated by a ribosome.

What is co translational translocation?

Co-translational translocation of a protein is specified by translation of an ER signal sequence that binds to the Signal Recognition Particle (SRP). SRP pauses translation by binding to the ribosome and causes the ribosome to associate with the ER by binding to the SRP receptor on the ER membrane.

What are different types of post-translational modifications and what is their functional significance?

These modifications include phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation and proteolysis and influence almost all aspects of normal cell biology and pathogenesis.

What are three types of post translational modifications?

These modifications include phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation and proteolysis and influence almost all aspects of normal cell biology and pathogenesis.

Which of the following is not a type of post translational modification?

3. Which of the following is not a post-translational modification? Explanation: DNA methylation is not a post-translational modification. It is a biological process in which DNA molecules are methylated.

Where does post transcriptional modification occur?

RNA Transport from the Nucleus to the Cytoplasm

Post-transcriptional modifications of pre-mRNA, such as capping, splicing, and polyadenylation, take place in the nucleus. After these modifications have been completed, the mature mRNA molecules have to be translocated into the cytoplasm, where protein synthesis occurs.

How do you identify post-translational modification?

Rather than performing a western blot to determine if a specific protein is modified, the sample is analyzed using a mass spectrometer. The investigator can identify a spectrum of proteins modified by a PTM using bottom-up peptide-based PTM proteomics [3, 8, 11].

Where does post-translational modification?

Post-translational modifications can occur on the amino acid side chains or at the protein's C- or N- termini. They can extend the chemical repertoire of the 20 standard amino acids by modifying an existing functional group or introducing a new one such as phosphate.

Is Methylation a post translational modification?

Methylation is an important protein posttranslational modification that not only regulates target gene transcription and expression, but also controls the activity of various signaling pathways.

What is co-translational targeting?

Co-translational protein targeting to the endoplasmic reticulum (ER), represents an evolutionary-conserved mechanism to target proteins into the secretory pathway. ... This triggers their delivery to the ER protein translocation channel, where they are directly translocated into the ER.

What does co-translational mean?

co·trans·la·tion·al

(kō'tranz-lā'shun-ăl), Any process involving the maturation or delivery of a protein that occurs during the process of translation.