Blood

Difference Between ITP and TTP

Difference Between ITP and TTP
  1. Is ITP and TTP the same?
  2. What is TTP syndrome?
  3. What is the difference between TTP and HUS?
  4. How does TTP cause thrombocytopenia?
  5. Can ITP turn into leukemia?
  6. How long can you live with TTP?
  7. How common is TTP?
  8. What drugs can cause TTP?
  9. How is TTP diagnosed?
  10. How do you get HUS disease?
  11. What is the treatment for HUS?
  12. What is atypical HUS?

Is ITP and TTP the same?

Thrombotic thrombocytopenic purpura (TTP) and idiopathic thrombocytopenic purpura (ITP) are two well recognized syndromes that are characterized by low platelet counts. In contrast, essential thrombocythemia (ET) is a myeloproliferative disease characterized by abnormally high platelet numbers.

What is TTP syndrome?

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder in which platelet clumps form in small blood vessels. This leads to a low platelet count (thrombocytopenia).

What is the difference between TTP and HUS?

HUS is related to thrombotic thrombocytopenic purpura (TTP), but it occurs more often in children and more often causes kidney failure, whereas TTP is more common among adults. The small blood clots that form in HUS block small blood vessels throughout the body, particularly those in the brain, heart, and kidneys.

How does TTP cause thrombocytopenia?

A lack of activity in the ADAMTS13 enzyme (a type of protein in the blood) causes thrombotic thrombocytopenic purpura (TTP). The ADAMTS13 gene controls the enzyme, which is involved in blood clotting. Not having enough enzyme activity causes overactive blood clotting.

Can ITP turn into leukemia?

ITP does not turn into a more serious blood disorder, like leukemia or aplastic anemia. It is usually not a sign that their child will later develop other autoimmune conditions, such as systemic lupus erythematosus (SLE or “lupus”).

How long can you live with TTP?

2) 10. All 11 patients died prior to their expected age of death (median difference, 30 years; range, 4–41 years). One patient died from relapsed TTP and another patient died from a myocardial infarction following recovery from a TTP relapse.

How common is TTP?

Thrombotic Thrombocytopenic Purpura is a rare blood disorder that is considered a true medical emergency. TTP is diagnosed at a rate of 3-4in 1 million people per year. Potentially fatal complications can result from internal blood clotting, with damage to critical organs such as the brain and heart.

What drugs can cause TTP?

Substances

How is TTP diagnosed?

Diagnosis. Laboratory studies for suspected TTP include a CBC, platelet count, blood smears, coagulation studies, BUN creatinine, and serum bilirubin and lactate dehydrogenase. The exact etiology of TTP is unknown.

How do you get HUS disease?

Hemolytic uremic syndrome (HUS) is a condition that can occur when the small blood vessels in your kidneys become damaged and inflamed. This damage can cause clots to form in the vessels. The clots clog the filtering system in the kidneys and lead to kidney failure, which could be life-threatening.

What is the treatment for HUS?

HUS is generally treated with medical care in the hospital. Close attention to fluid volume is very important. This potentially includes intravenous (IV) fluids and nutritional supplementation by IV or tube feeding. A transfusion of blood may also be needed.

What is atypical HUS?

Atypical hemolytic uremic syndrome (aHUS) is an extremely rare disease characterized by low levels of circulating red blood cells due to their destruction (hemolytic anemia), low platelet count (thrombocytopenia) due to their consumption and inability of the kidneys to process waste products from the blood and excrete ...

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