Difference Between Cyanocobalamin and Hydroxocobalamin

Cyanocobalamin is usually converted to hydroxocobalamin in the serum, whereas hydroxocobalamin is converted to either methylcobalamin or 5-deoxyadenosyl cobalamin. Cobalamins circulate bound to serum proteins called transcobalamins (TC) and haptocorrins.

1. Is Hydroxocobalamin better than cyanocobalamin?
2. Which form of vitamin B12 is best?
3. What is Hydroxocobalamin used for?
4. What are the 4 types of B12?
5. What are the neurological symptoms of B12 deficiency?
6. What is the brand name for cyanocobalamin?
7. What are the side effects of cyanocobalamin?
8. When should I take B12 morning or night?
9. What medications should not be taken with B12?
10. What is Combedi?
11. How often should Hydroxocobalamin be given?
12. Can low B12 cause hair loss?

Is Hydroxocobalamin better than cyanocobalamin?

The BNF states that hydroxocobalamin has completely replaced cyanocobalamin as the first choice for replacement therapy. It is certainly more convenient for the majority of patients who require lifelong treatment because it needs to be given only every three months.

Which form of vitamin B12 is best?

The body may absorb cyanocobalamin better, while methylcobalamin has a higher retention rate. Both can prevent B12 deficiency, but methylcobalamin should be combined with adenosylcobalamin for best results.

What is Hydroxocobalamin used for?

Hydroxocobalamin is a manufactured version of the vitamin B12. It is used to treat and prevent vitamin B12 deficiency anaemia (when you have low levels of this vitamin in the body).

What are the 4 types of B12?

While known commonly as 'Vitamin B12' it does, in fact, exist in four very similar chemical forms, namely:

• Methylcobalamin.
• Adenosylcobalamin.
• Cyanocobalamin.
• Hydroxocobalamin.

What are the neurological symptoms of B12 deficiency?

A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as:

• vision problems.
• memory loss.
• pins and needles (paraesthesia)
• loss of physical co-ordination (ataxia), which can affect your whole body and cause difficulty speaking or walking.

What is the brand name for cyanocobalamin?

Cyanocobalamin is available under the following different brand names: Vitamin B12, Nascobal, Athlete, Calomist, Cobalamin, Cobex, Crystamine, Prime, Rubramine PC, Vibisone, and Eligen B12.

What are the side effects of cyanocobalamin?

Side Effects

• Abdominal or stomach pain.
• bleeding from the gums or nose.
• blue lips and fingernails.
• coughing that sometimes produces a pink frothy sputum.
• decreased urine output.
• difficult, fast, noisy breathing, sometimes with wheezing.
• dilated neck veins.
• extreme fatigue.

When should I take B12 morning or night?

You may need to take vitamin B-12 separately from the above drugs and supplements — say, one in the morning and one at night — so you can get the full dose of vitamin B-12. Don't take vitamin B-12 supplements if you have sensitivities or allergies to vitamin B-12, cobalt, and any other ingredients.

What medications should not be taken with B12?

Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers ...

What is Combedi?

Hydroxocobalamin is a man-made injectable form of vitamin B12 used to treat low levels (deficiency) of this vitamin. Vitamin B12 helps your body use fat and carbohydrates for energy and make new protein. It is also important for normal blood, cells, and nerves.

How often should Hydroxocobalamin be given?

If you need regular injections of vitamin B12, cyanocobalamin would need to be given once a month, whereas hydroxocobalamin can be given every 3 months.

Can low B12 cause hair loss?

When vitamin B12 levels are low, your hair follicles may not be able to grow new hair as efficiently, resulting in hair loss. A vitamin B12 deficiency can also cause symptoms of anemia, which is associated with low iron levels, hair thinning, and hair loss.