Siadh

Difference Between CSS and SIADH

Difference Between CSS and SIADH
  1. What is the difference between DI and Siadh?
  2. What is the most common cause of Siadh?
  3. Which signs and symptoms are consistent with Siadh?
  4. How is Siadh diagnosed?
  5. Does Siadh cause increased urine output?
  6. Is sodium high or low in DI?
  7. Is Siadh curable?
  8. How serious is Siadh?
  9. Does Siadh go away?
  10. What is used to treat Siadh?
  11. What happens if you have too much antidiuretic hormone?

What is the difference between DI and Siadh?

In SIADH, ADH is not suppressed resulting in water retention and significant electrolyte abnormalities. In DI, there is either decreased production of ADH (central DI), or normal ADH secretion with resistance in the kidneys to its effects (nephrogenic DI). The net result of DI is large volume diuresis of dilute urine.

What is the most common cause of Siadh?

The most common causes include medication effects, fluid retention and syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Which signs and symptoms are consistent with Siadh?

What are the symptoms of SIADH?

How is Siadh diagnosed?

How is SIADH diagnosed? In addition to a complete medical history and physical examination, your child's doctor will order blood tests to measure sodium, potassium chloride levels and osmolality (concentration of solution in the blood). These tests are necessary to confirm a diagnosis of SIADH.

Does Siadh cause increased urine output?

In SIADH, hyponatremia is caused by water retention due to inappropriate secretion of antidiuretic hormone (ADH) (10-15). But in CSWS, hyponatremia is associated with high urine output, high urine sodium concentration, and plasma volume depletion (16).

Is sodium high or low in DI?

Serum and urine sodium concentrations (SNa, UNa) and osmolarity (SOsm and UOsm) can help distinguish DI, SIADH, and cerebral salt wasting. With DI, SNa and SOsm are high (latter usually > 300) while UOsm is low (usually 50-200).

Is Siadh curable?

SIADH should be treated to cure symptoms. While this is undisputed in the presence of grave or advanced symptoms, the clinical role and the indications for treatment in the presence of mild to moderate symptoms are currently unclear.

How serious is Siadh?

A.

Symptoms of SIADH are those seen in hyponatremia. Mild hyponatremia can result in occult cognitive slowing and gait abnormalities particularly in the elderly population, along with nonspecific symptoms of headache and nausea. In more severe cases, hyponatremia can lead to seizure, coma and even death.

Does Siadh go away?

Chronic hyponatremia is associated with nervous system problems such as poor balance and poor memory. Many causes of SIADH are reversible.

What is used to treat Siadh?

Urea. Urea is used for the treatment of SIADH refractory to or in patients noncompliant with other therapies or when other therapies are not available. Urea is known to promote diuresis.

What happens if you have too much antidiuretic hormone?

Excess ADH. When there's too much ADH in your blood, syndrome of inappropriate ADH (SIADH) may be the cause. If the condition is acute, you may have a headache, nausea, or vomiting. In severe cases, coma and convulsions can occur.

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